At the begining, the Hospicio de San Fernando was situated in a small house in the Street of Santa Isabel. Due to the bad conditions, in the year 1674, it was moved to the Fuencarral Street. Fortyseven years later (1721). this houses were demolished so that the definitive building could be built. Of the first building, is only conserved the Chapel.
XXI century: the reform of the museum begins. This reform is the most important one since the fundation. Its facilities were renewed and has spaces dedicated for didactic activities and temporal exhibitions. The museum has created a museological project reconverting its collections so that the exhibition is more innovative and allows to show the historical and social evolution of Madrid.